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Persistence of Initial Infection in Recurrent Cryptococcus Neuformans Meningitis Lancet 341:595-596, Spitzer,E.D.,et al, 1993 See this aricle in Pubmed Article Abstract Patients with cryptococcal meningitis tend to have recurrence of infection.Although the original strain of Cyptococcus neoformans is assumed to persist in recurrent infections,this assumption has not been tested.Southern blot hybridisation with two genomic DNA probes and pulsed- fieldelectophoresis of intact chromosomes were used to investigate the genetic relation between initial and relapse isolates of C neoformans from patients with recurrent crytococcal meningitis.Eleven isolates were obtained from four patients(three with AIDS,one with leukemia).Isolates from each patients could be distinguished from those of the other patients;however,each patient's intial and recurrence isolates were clonally related.Our results provide strong evidence that clinical recurrences ofcyyptococcal meningitis result from persistence or the original infecting strain.

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(click to filter results - removes previous filter) acquired immunodeficiency syndrome cryptococcal meningitis DNA probes meningitis meningitis,recurrent meningitis,relapse recurrent RFLPs

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